Gregory Marslin, Divya B, Mary Revina Ann, Viji M M Hipolith, Kalaichelvan V K, Palanivel V
Department of pharmacology, Annamalai University, Chidambaram, India.
Asian Pac J Trop Biomed. 2013 Jul;3(7):554-6. doi: 10.1016/S2221-1691(13)60112-4.
To evaluate the anti-ulcer activity and acute toxicity of Ficus religiosa (F. religiosa) leaf ethanolic extract in animal models.
Anti-ulcer activity of F. religiosa ethanolic extract (250 and 500 mg/kg body weight) was studied on stress induced ulcer animal models. Ranitidine was used as standard. The anti-ulcer activity of F. religiosa was evaluated with the help of ulcer area and histopatholgical examination. Preliminary phyto-chemical screening and acute toxicity studies of F. religiosa also carried out.
Results showed that the extract treatments prevented ulcer area and gastric secretion in a dose-dependent manner. Administration of 2 000 mg/kg extract did not show any acute toxicity in albino mice. Preliminary phytochemical analysis identified the presence of flavonoids in the ethanolic extract of F. religiosa.
The extract is non-toxic even at relatively high concentrations. The anti-ulcer activity is probably due to the presence of flavanoids.
在动物模型中评估菩提树（Ficus religiosa）叶乙醇提取物的抗溃疡活性和急性毒性。
在应激诱导的溃疡动物模型上研究菩提树乙醇提取物（250和500毫克/千克体重）的抗溃疡活性。雷尼替丁用作标准对照。借助溃疡面积和组织病理学检查评估菩提树的抗溃疡活性。还进行了菩提树的初步植物化学筛选和急性毒性研究。
结果表明，提取物处理以剂量依赖性方式预防了溃疡面积和胃液分泌。给予2000毫克/千克提取物在白化小鼠中未显示任何急性毒性。初步植物化学分析确定菩提树乙醇提取物中存在黄酮类化合物。
该提取物即使在相对高的浓度下也无毒。抗溃疡活性可能归因于黄酮类化合物的存在。
