Environmental and Molecular Toxicology Laboratory, PG Department of Studies and Research in Zoology, Karnatak University, KUD Staff Qt. B-3, Dharwad, 580003, Karnataka, India.
Environ Monit Assess. 2013 Dec;185(12):10191-9. doi: 10.1007/s10661-013-3323-z. Epub 2013 Jul 9.
This study examined the effect of lethal (4.5 μg/l) and sublethal (0.45 μg/l) malathion levels on oxidative stress responses of the freshwater edible fish, Labeo rohita. Fish were exposed to lethal (1-4 days) and sublethal (1, 5, 10, and 15 days) periods. In the present study, catalase and protease activity, hydrogen peroxide, malondialdehyde, protein carbonyls, and free amino acids levels increased in the gill, liver, and kidney tissues of fish exposed to lethal and sublethal concentrations of malathion except protein content. Time- and concentration-dependent induction/reduction of the above parameters by lethal and sublethal concentrations of malathion was observed in the tissues (the gill, liver, and kidney) of L. rohita. Thus, the results clearly infer oxidative damage and decline in antioxidant defense due to malathion-induced oxidative stress.
本研究考察了致死浓度（4.5μg/l）和亚致死浓度（0.45μg/l）马拉硫磷对淡水食用鱼罗非鱼氧化应激反应的影响。鱼被暴露在致死浓度（1-4 天）和亚致死浓度（1、5、10 和 15 天）下。在本研究中，过氧化氢酶和蛋白酶活性、过氧化氢、丙二醛、蛋白质羰基和游离氨基酸水平在暴露于致死和亚致死浓度马拉硫磷的鱼的鳃、肝和肾组织中增加，除了蛋白质含量。在罗非鱼的组织（鳃、肝和肾）中，观察到致死和亚致死浓度马拉硫磷对上述参数的时间和浓度依赖性诱导/降低。因此，结果清楚地推断出由于马拉硫磷诱导的氧化应激导致的氧化损伤和抗氧化防御的下降。
