King's College London Dental Institute, Departmentof Periodontology, Guy's Hospital Campus, LondonSE1 9RT, UK.
Bone Joint Res. 2013 Jun 14;2(6):102-11. doi: 10.1302/2046-3758.26.2000142. Print 2013.
To review the systemic impact of smoking on bone healing as evidenced within the orthopaedic literature.
A protocol was established and studies were sourced from five electronic databases. Screening, data abstraction and quality assessment was conducted by two review authors. Prospective and retrospective clinical studies were included. The primary outcome measures were based on clinical and/or radiological indicators of bone healing. This review specifically focused on non-spinal orthopaedic studies.
Nine tibia studies and eight other orthopaedic studies were considered for systematic review. Of these 17 studies, 13 concluded that smoking negatively influenced bone healing.
Smoking has a negative effect on bone healing, in terms of delayed union, nonunion and more complications.
回顾吸烟对骨骼愈合的系统影响，这在骨科文献中有明确记载。
制定了方案，并从五个电子数据库中获取了研究。两位综述作者进行了筛选、数据提取和质量评估。纳入了前瞻性和回顾性临床研究。主要结局指标基于骨骼愈合的临床和/或影像学指标。本综述特别关注非脊柱骨科研究。
有 9 项胫骨研究和 8 项其他骨科研究被纳入系统评价。在这 17 项研究中，有 13 项研究得出吸烟对骨骼愈合有负面影响的结论。
吸烟对骨骼愈合有负面影响，表现为延迟愈合、不愈合和更多并发症。
