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母亲体内分析出生时健康的季节性模式。

Within-mother analysis of seasonal patterns in health at birth.

机构信息

Center for Health and Wellbeing, Princeton University, Princeton, NJ 08540, USA.

出版信息

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12265-70. doi: 10.1073/pnas.1307582110. Epub 2013 Jul 8.

Abstract

A large literature describes relationships between month of birth, birth weight, and gestation. These relationships are hypothesized to reflect the causal impact of seasonal environmental factors. However, recent work casts doubt on this interpretation by showing that mothers with lower socioeconomic status are more likely to give birth in months that are associated with poorer birth outcomes. Seasonality in the numbers of conceptions in different months can also induce a mechanical correlation between preterm birth and month of birth. This paper analyzes the seasonality of health at birth using a large sample of 647,050 groups of US siblings representing 1,435,213 children. By following the same mother over time, we eliminate differences in fixed maternal characteristics as an explanation for seasonal differences in health at birth. We find a sharp trough in gestation length among babies conceived in May, which corresponds to an increase in prematurity of more than 10%. Birth weight conditional on gestation length, however, is found to be strongly hump-shaped over the year, with 8-9 additional g for summer conceptions. We examine several potential mechanisms for explaining seasonality in birth outcomes that have generally been dismissed in the literature on seasonality in rich countries, notably disease prevalence and nutrition. The May trough in gestation length coincides with a higher influenza prevalence in January and February, when these babies are nearing full term, whereas the hump shape in birth weight is associated with a similar pattern in pregnancy weight gain.

摘要

大量文献描述了出生月份、出生体重和胎龄之间的关系。这些关系的假设反映了季节性环境因素的因果影响。然而,最近的研究工作对这种解释提出了质疑,表明社会经济地位较低的母亲更有可能在与较差出生结果相关的月份分娩。不同月份受孕数量的季节性也会导致早产和出生月份之间产生机械相关性。本文使用代表 1435213 名儿童的 647050 组美国兄弟姐妹的大量样本,分析了出生时的季节性健康状况。通过随着时间的推移跟踪同一位母亲,我们消除了固定的产妇特征差异,作为出生时健康季节性差异的解释。我们发现五月份受孕的婴儿胎龄明显缩短,这对应于早产率增加了 10%以上。然而,出生体重与胎龄的关系呈强烈的驼峰状,夏季受孕的婴儿体重增加了 8-9 克。我们研究了几种可能的机制来解释出生结果的季节性,这些机制在富裕国家季节性文献中通常被忽视,特别是疾病流行和营养。胎龄在五月份的低谷与 1 月和 2 月流感流行相吻合,此时这些婴儿即将足月,而出生体重的驼峰形状与妊娠体重增加的类似模式相关。

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Within-mother analysis of seasonal patterns in health at birth.母亲体内分析出生时健康的季节性模式。
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