University of Louvain, Institute of Neuroscience, Developmental Neurobiology Group, Avenue Mounier 73, Box B1.73.16, 1200 Brussels, Belgium.
Nat Rev Neurosci. 2013 Aug;14(8):525-35. doi: 10.1038/nrn3525. Epub 2013 Jul 10.
Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and refers to the global coordination of cell behaviour in the plane of a tissue and, by extension, to the signalling pathways that control it. PCP is most evident in cell sheets, and research into PCP was for years confined to studies in Drosophila melanogaster. However, PCP has more recently emerged as an important phenomenon in vertebrates, in which it regulates various developmental processes and is associated with multiple disorders. In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance.
平面细胞极性（PCP）与单细胞的固有极性互补，是指组织平面上细胞行为的全局协调，并且可以扩展到控制它的信号通路。PCP 在细胞层中最为明显，PCP 的研究多年来仅限于黑腹果蝇的研究。然而，PCP 最近在脊椎动物中成为一个重要现象，在脊椎动物中，它调节各种发育过程，并与多种疾病有关。特别是，核心 PCP 基因对神经系统的发育和功能至关重要。它们参与神经管闭合、室管膜极性、神经元迁移、树突生长和轴突导向。
