Santucci B, Manna F, Cristaudo A, Cannistraci C, Capparella M R, Picardo M
Servizio Allergologia, Istituto S. Maria e S. Gallicano, Roma, Italy.
Contact Dermatitis. 1990 May;22(5):253-6. doi: 10.1111/j.1600-0536.1990.tb01591.x.
11 nickel-sensitive subjects were given a gradually increasing daily oral intake of NiSO4 in water. The treatment lasted from between 49 and 152 days and the total intake ranged from 56.43 to 271.70 mg of Ni++. Ni serum concentrations were repeatedly assayed. While the values varied irregularly in the first assessments, they then tended to diminish and to be lower than those found at basal level. The ratio of Ni serum concentration to oral intake demonstrated that, as the doses administered increased, the absorption of nickel decreased. We hypothesize that this trend might be due to an intestinal adaptivity that reduces nickel absorption.
11名对镍敏感的受试者每天口服逐渐增加剂量的硫酸镍水溶液。治疗持续49至152天，镍离子的总摄入量在56.43至271.70毫克之间。多次检测血清镍浓度。虽然在最初的检测中数值变化不规则，但随后趋于下降，且低于基础水平时的数值。血清镍浓度与口服摄入量的比值表明，随着给药剂量增加，镍的吸收减少。我们推测这种趋势可能是由于肠道适应性降低了镍的吸收。
