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基于氨基酸特性的蛋白质序列系统发育重建。

Phylogeny reconstruction for protein sequences based on amino acid properties.

作者信息

Schmidt W

机构信息

Max-Delbrück-Center for Molecular Medicine, Department of Bioinformatics, Berlin-Buch, Germany.

出版信息

J Mol Evol. 1995 Oct;41(4):522-30. doi: 10.1007/BF00160324.

Abstract

This paper presents an essentially new method used to construct phylogenetic trees from related amino acid sequences. The method is based on a new distance measure which describes sequence relationships by means of typical steric and physicochemical properties of the amino acids and is advantageous in some essential points. The method was applied to different sets of protein sequences and the results were compared with other well-established methods.

摘要

本文提出了一种从相关氨基酸序列构建系统发育树的全新方法。该方法基于一种新的距离度量,该距离度量通过氨基酸的典型空间和物理化学性质来描述序列关系,并且在一些关键方面具有优势。该方法被应用于不同的蛋白质序列集,并将结果与其他成熟的方法进行了比较。

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