University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.
Org Lett. 2013 Jul 19;15(14):3790-3. doi: 10.1021/ol401771a. Epub 2013 Jul 10.
Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.
三氟甲基取代的丙二烯与多聚甲醛在钌催化下发生还原偶联反应,形成单一区域异构体的羟羟甲基化产物。该方法能够生成含 CF3 的全碳季立体中心。