Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
J Am Chem Soc. 2017 Jun 21;139(24):8114-8117. doi: 10.1021/jacs.7b04374. Epub 2017 Jun 12.
Using an iridium catalyst modified by PhanePhos, CF-allenes react with methanol to form branched products of hydrohydroxymethylation as single regioisomers with excellent levels of enantiomeric enrichment. This hydrogen autotransfer process enables catalytic enantioselective formation of acyclic CF-bearing all-carbon quaternary stereocenters in the absence of stoichiometric metals or byproducts.
使用 PhanePhos 修饰的铱催化剂,CF-丙二烯与甲醇反应,以单一区域异构体的形式生成支化的氢羟甲基化产物,具有优异的对映体富集度。这种氢自动转移过程能够在没有化学计量金属或副产物的情况下,催化非循环 CF 负载全碳季立体中心的对映选择性形成。