使用一种新型技术追踪在一项为期较短的杀微生物剂试验（MTN-007）中对产品使用的依从性。
Use of a novel technology to track adherence to product use in a microbicide trial of short duration (MTN-007).
机构信息
HIV Center for Clinical and Behavioral Studies, NY State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 15, New York, NY, 10032, USA,
出版信息
AIDS Behav. 2013 Nov;17(9):3101-7. doi: 10.1007/s10461-013-0549-2.
Adherence measurement in microbicide trials is challenging. To decrease recall and social desirability bias, we used an interactive voice response system (IVR) in a rectal microbicide trial. Forty-six participants were asked to report product use daily for 1 week. Participants received an incentive per call plus a bonus for calling every day. We examined adherence to calling the IVR and to gel use; we compared the latter to applicator counts. Adherence to calling the IVR daily was high (mean = 89.9 %, SD = 20.7 %). Adherence to gel use per IVR was very good (mean = 90.7 %, SD = 19.1 %), and consistent with applicator counts in 80.4 % of cases. Neither adherence to calling nor gel use were associated with temporal factors like day calls started, number of days since first call, or weekday vs. weekend. Daily reporting allowed identification of irregular product use. IVR appears useful for daily reporting in brief trials.
在杀微生物剂试验中，坚持度的测量具有挑战性。为了减少回忆和社交期望偏差，我们在直肠杀微生物剂试验中使用了交互式语音应答系统（IVR）。46 名参与者被要求在一周内每天报告产品使用情况。参与者每通电话可获得一次奖励，每天打电话可获得额外奖励。我们检查了参与者对 IVR 电话和凝胶使用的坚持程度；我们将后者与使用计数器的情况进行了比较。参与者每天拨打 IVR 的坚持度很高（平均=89.9%，标准差=20.7%）。根据 IVR 报告的凝胶使用坚持度非常好（平均=90.7%，标准差=19.1%），在 80.4%的情况下与使用计数器的结果一致。无论是拨打 IVR 的坚持度还是凝胶使用的坚持度都与时间因素无关，如开始打电话的天数、第一次打电话以来的天数或工作日与周末。每日报告可识别不规则产品使用情况。IVR 似乎可用于简短试验中的每日报告。
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