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基础科学中的母性行为:转化研究与临床适用性。

Maternal behavior in basic science: translational research and clinical applicability.

作者信息

Pires Gabriel Natan, Tufik Sergio, Giovenardi Márcia, Andersen Monica Levy

出版信息

Einstein (Sao Paulo). 2013 Apr-Jun;11(2):256-60. doi: 10.1590/s1679-45082013000200021.

DOI:10.1590/s1679-45082013000200021
PMID:23843071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4872904/
Abstract

Clinical aspects of the mother-infant relationship and related issues are well studied and very relevant to medical practice. Nevertheless, some approaches in this context cannot plausibly be investigated in humans due to their ethical implications and to the potential harm to the mother's and child's health. Studies on maternal behavior in animals have evident importance to some clinical fields, such as psychiatry and psychology, particularly considering topics, including mother-infant relationship, postpartum depression, cognitive and behavioral development of children, and associated issues. Hence, this theoretical article draws attention to the clinical applicability of studies about maternal behavior in animals to psychobiology, taking into account a translational perspective.

摘要

母婴关系的临床方面及相关问题已得到充分研究,且与医学实践密切相关。然而,鉴于某些方法在伦理方面的影响以及对母婴健康的潜在危害,无法在人体中对其进行合理研究。动物母性行为研究对某些临床领域,如精神病学和心理学具有明显的重要性,特别是在考虑母婴关系、产后抑郁、儿童认知与行为发展以及相关问题等主题时。因此,这篇理论文章从转化医学的角度出发,提请人们关注动物母性行为研究在心理生物学中的临床适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27f/4872904/168a1bf1e781/1679-4508-eins-11-02-0256-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27f/4872904/168a1bf1e781/1679-4508-eins-11-02-0256-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27f/4872904/168a1bf1e781/1679-4508-eins-11-02-0256-gf01.jpg

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本文引用的文献

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Hidden Markov model analysis of maternal behavior patterns in inbred and reciprocal hybrid mice.近交系和回交系小鼠母性行为模式的隐马尔可夫模型分析。
PLoS One. 2011 Mar 8;6(3):e14753. doi: 10.1371/journal.pone.0014753.
2
Epigenetics. The seductive allure of behavioral epigenetics.表观遗传学。行为表观遗传学的诱人魅力。
Science. 2010 Jul 2;329(5987):24-7. doi: 10.1126/science.329.5987.24.
3
Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams.新生儿关节炎会扰乱成年大鼠后代及其母鼠的睡眠和行为。
Eur J Pain. 2010 Nov;14(10):985-91. doi: 10.1016/j.ejpain.2010.03.008. Epub 2010 Apr 18.
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Progesterone and maternal aggressive behavior in rats.孕激素与大鼠的母性行为攻击。
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c-Fos identification of neuroanatomical sites associated with haloperidol and clozapine disruption of maternal behavior in the rat.c-Fos 鉴定与氟哌啶醇和氯氮平破坏大鼠母爱行为相关的神经解剖部位。
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Maternal fatigue and its relationship to the caregiving environment.
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Bottle feeding simulates child loss: postpartum depression and evolutionary medicine.瓶喂模拟了孩子的丧失:产后抑郁和进化医学。
Med Hypotheses. 2010 Jan;74(1):174-6. doi: 10.1016/j.mehy.2009.07.016. Epub 2009 Aug 8.
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Offspring-exposure reduces depressive-like behaviour in the parturient female rat.子代暴露可降低分娩期雌性大鼠的抑郁样行为。
Behav Brain Res. 2009 Jan 30;197(1):55-61. doi: 10.1016/j.bbr.2008.08.001. Epub 2008 Aug 9.
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Epigenetics: behavioral influences on gene function, part I. Maternal behavior permanently affects adult behavior in offspring.
J Am Acad Child Adolesc Psychiatry. 2008 Mar;47(3):240-244. doi: 10.1097/CHI.0b013e3181635e13.
10
Effects of treating postnatal depression on mother-infant interaction and child development: systematic review.产后抑郁症治疗对母婴互动及儿童发育的影响:系统评价
Br J Psychiatry. 2007 Nov;191:378-86. doi: 10.1192/bjp.bp.106.032789.