钯介导的 C-H 活化/环化反应高效合成羟基异吲哚酮。
Efficient synthesis of hydroxyl isoindolones by a Pd-mediated C-H activation/annulation reaction.
机构信息
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, PR China.
出版信息
Chemistry. 2013 Aug 19;19(34):11184-8. doi: 10.1002/chem.201302031. Epub 2013 Jul 10.
Radical reaction: A convenient synthesis of hydroxyl isoindolones by a Pd-catalyzed CH activation/annulation reaction with near "click chemistry" efficiency is presented (see scheme; TBHP=tert-butyl hydrogen peroxide). This methodology features short reaction times (10-30 min), high atom economy, wide substrate scope (22 examples), and good reaction yields (up to 93 %).
自由基反应
通过 Pd 催化的 CH 活化/环化反应，以近乎“点击化学”的效率实现了羟基异吲哚酮的简便合成（见方案；TBHP=叔丁基过氧化氢）。该方法具有反应时间短（10-30 分钟）、原子经济性高、底物范围广（22 个实例）和反应收率好（高达 93%）的特点。
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