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子痫前期患者胎盘的微小RNA分析：新结果与已发表结果的比较。

MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

作者信息

Betoni James S, Derr Kimberly, Pahl Matthew C, Rogers Laura, Muller Corinna L, Packard Roger E, Carey David J, Kuivaniemi Helena, Tromp Gerard

机构信息

Department of Maternal Fetal Medicine, Geisinger Clinic , Danville, PA , USA .

出版信息

Hypertens Pregnancy. 2013 Nov;32(4):321-39. doi: 10.3109/10641955.2013.807819. Epub 2013 Jul 11.

DOI:10.3109/10641955.2013.807819
PMID:23844600
Abstract

OBJECTIVE

The aim was to identify differences in microRNA expression between patients with and without preeclampsia.

METHODS

Microarray-based study was carried out with placental samples.

RESULTS

Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets.

CONCLUSION

The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.

摘要

目的

旨在确定子痫前期患者与非子痫前期患者之间微小RNA表达的差异。

方法

对胎盘样本进行基于微阵列的研究。

结果

将之前的八项研究与当前研究进行比较，共发现138种微小RNA；然而，其中只有20/138（14%）在不止一项研究中出现，且结果在变化方向上一致。对这20种微小RNA进行生物信息学分析，确定了其mRNA靶标的广泛生物学功能，包括细胞凋亡和细胞运动。

结论

微小RNA表达与子痫前期之间的关联表明，微小RNA在子痫前期病理生物学中可能发挥作用。

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MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.子痫前期患者胎盘的微小RNA分析：新结果与已发表结果的比较。
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