Dani Carlo, Bresci Cecilia, Berti Elettra, Ottanelli Serena, Mello Giorgio, Mecacci Federico, Breschi Rita, Hu Xiaoyu, Tenori Leonardo, Luchinat Claudio
Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence , Florence , Italy .
J Matern Fetal Neonatal Med. 2014 Apr;27(6):537-42. doi: 10.3109/14767058.2013.823941. Epub 2013 Sep 12.
Maternal diabetes increases the risk of perinatal mortality and morbidity, but the maintenance of antenatal normal glucose serum prevents the majority of neonatal complications. The aim of our study is to compare the metabolomic profile of infants of gestational diabetic mothers (IGDMs) to that of infants of healthy mothers to evaluate if differences remain despite a strict control of gestational diabetes.
We performed the metabolomics study in cord serum sampled from 30 term IGDMs and 40 controls recording the occurrence of the most frequent complications in IGDMs.
We demonstrated that IGDMs have lower level of glucose and higher level of pyruvate, histidine, alanine, valine, methionine, arginine, lysine, hypoxanthine, lipoprotein and lipid than controls, but we did not find any clinical differences.
Our results suggest that prolonged fetal exposure to hyperglycemia during pregnancy can change neonatal metabolomic profile at birth without affecting the clinical course.
孕产妇糖尿病会增加围产期死亡率和发病率，但孕期维持正常血糖水平可预防大多数新生儿并发症。我们研究的目的是比较妊娠期糖尿病母亲所生婴儿（IGDMs）与健康母亲所生婴儿的代谢组学特征，以评估尽管对妊娠期糖尿病进行了严格控制，差异是否依然存在。
我们对30名足月IGDMs母亲和40名对照母亲的脐带血进行了代谢组学研究，并记录了IGDMs中最常见并发症的发生情况。
我们发现，与对照组相比，IGDMs的葡萄糖水平较低，而丙酮酸、组氨酸、丙氨酸、缬氨酸、蛋氨酸、精氨酸、赖氨酸、次黄嘌呤、脂蛋白和脂质水平较高，但我们未发现任何临床差异。
我们的结果表明，孕期胎儿长期暴露于高血糖环境可改变出生时新生儿的代谢组学特征，但不影响临床病程。
