Adv Med Sci. 2013;58(2):207-15. doi: 10.2478/ams-2013-0023.
Plasma levels of selected hematopoietic cytokines: interleukin 3 ( IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF), and the tumor marker carcinoma antigen 15-3 (CA 15-3) in breast cancer (BC) patients were investigated and compared to control groups: benign breast tumor patients and healthy subjects.
MATERIAL/METHODS: Cytokine levels were determined by ELISA, CA 15-3 - using the CMIA method.
A significant differences in the concentration of cytokines (with the exception of IL-3) and CA15-3 between the groups of BC patients, benign breast tumor patients and the healthy controls have been demonstrated. M-CSF has demonstrated higher or equal to CA 15-3 values of diagnostic sensitivity, specificity and the predictive values of positive and negative test results. The M-CSF area under the ROC curve (AUC) was the largest from all the cytokines tested and marginally lower than the AUC of CA 15-3.
These findings suggest the usefulness of M-CSF in diagnosing breast cancer, especially when discriminating between cancer and non-carcinoma lesions.
检测并比较乳腺癌（BC）患者与对照组（良性乳腺肿瘤患者和健康受试者）血浆中选定的造血细胞因子（白细胞介素 3 [IL-3]、干细胞因子 [SCF]、粒细胞-巨噬细胞集落刺激因子 [GM-CSF]、粒细胞集落刺激因子 [G-CSF]和巨噬细胞集落刺激因子 [M-CSF]）和肿瘤标志物癌抗原 15-3（CA 15-3）的水平。
材料/方法：采用 ELISA 法检测细胞因子水平，采用 CMIA 法检测 CA 15-3。
BC 患者、良性乳腺肿瘤患者和健康对照组之间的细胞因子（除 IL-3 外）和 CA15-3 浓度存在显著差异。M-CSF 的诊断灵敏度、特异性和阳性及阴性预测值均高于或等于 CA 15-3。在所有检测的细胞因子中，M-CSF 的 ROC 曲线下面积（AUC）最大，略低于 CA 15-3 的 AUC。
这些发现表明 M-CSF 可用于诊断乳腺癌，尤其是在区分癌症和非癌性病变方面。
