Ondra S L, Troupp H, George E D, Schwab K
Division of Neurosurgery, Walter Reed Army Medical Center, Washington, D.C.
J Neurosurg. 1990 Sep;73(3):387-91. doi: 10.3171/jns.1990.73.3.0387.
The authors have updated a series of 166 prospectively followed unoperated symptomatic patients with arteriovenous malformations (AVM's) of the brain. Follow-up data were obtained for 160 (96%) of the original population, with a mean follow-up period of 23.7 years. The rate of major rebleeding was 4.0% per year, and the mortality rate was 1.0% per year. At follow-up review, 23% of the series were dead from AVM hemorrhage. The combined rate of major morbidity and mortality was 2.7% per year. These annual rates remained essentially constant over the entire period of the study. There was no difference in the incidence of rebleeding or death regardless of presentation with or without evidence of hemorrhage. The mean interval between initial presentation and subsequent hemorrhage was 7.7 years.
作者对166例有症状的未手术治疗的脑动静脉畸形（AVM）患者进行了前瞻性随访，并更新了相关数据。在最初的166例患者中，有160例（96%）获得了随访数据，平均随访期为23.7年。每年的大出血率为4.0%，死亡率为1.0%。在随访复查时，该系列患者中有23%死于AVM出血。每年的严重致残率和死亡率之和为2.7%。在整个研究期间，这些年发生率基本保持不变。无论最初就诊时有无出血证据，再出血或死亡的发生率均无差异。首次就诊与随后出血之间的平均间隔时间为7.7年。
