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[益生菌在儿科的临床应用]

[Clinical applications of the use of probiotics in pediatrics].

作者信息

Álvarez-Calatayud Guillermo, Pérez-Moreno Jimena, Tolín Mar, Sánchez César

机构信息

Sección de Gastroenterología y Nutrición Pediátrica, Hospital General Universitario Gregorio Marañón, Madrid, España.

出版信息

Nutr Hosp. 2013 May-Jun;28(3):564-74. doi: 10.3305/nh.2013.28.3.6603.

Abstract

INTRODUCTION

The use of probiotics supposes a novel advance in the field of Pediatrics since they can be useful in the prevention and treatment of many gastrointestinal pathologies, constituting one more element in our therapeutic arsenal.

OBJECTIVE

This article presents an updated review of the scientific literature on the use of probiotics in paediatrics, mainly in gastrointestinal problems with alteration in the intestinal microbiota describing the main applications of the use of probiotics and prebiotics in childhood and reviewing the future lines of research.

RESULTS AND CONCLUSIONS

Although there enough scientific evidence in various pathologies, the use of probiotics is not entirely incorporated into the clinical practice of pediatricians. It is used in the context of the gastrointestinal diseases (acute infectious diarrhea, diarrhea associated with antibiotics, bacterial overcast) and, more recently, in chronic inflammatory processes such as inflammatory bowel disease or functional disorders as colic infant or constipation. Also have been assessed their beneficial effect in extraintestinal alterations, such as the allergies (atopic dermatitis) or the effects on respiratory or urogenital mucosae and, in recent years, in the prevention of pathology of the preterm newborn and in the H. pylori infection. In addition there are several lines of research open in nutritional supplementation with probiotics. and prebiotics. Each strain probiotics should be studied individually and extensively to determine its efficacy and safety in all situations in which their employment may be advisable.

摘要

引言

益生菌的使用是儿科学领域的一项新进展,因为它们可用于预防和治疗多种胃肠道疾病,成为我们治疗手段中的又一个要素。

目的

本文对儿科学中益生菌使用的科学文献进行了更新综述,主要涉及肠道微生物群改变的胃肠道问题,描述了益生菌和益生元在儿童期的主要应用,并回顾了未来的研究方向。

结果与结论

尽管在各种疾病中有足够的科学证据,但益生菌的使用并未完全纳入儿科医生的临床实践。它用于胃肠道疾病(急性感染性腹泻、抗生素相关性腹泻、细菌过度生长)的情况,以及最近用于慢性炎症过程,如炎症性肠病或功能性疾病,如婴儿腹绞痛或便秘。也评估了它们在肠外改变中的有益作用,如过敏(特应性皮炎)或对呼吸道或泌尿生殖黏膜的影响,以及近年来在预防早产儿疾病和幽门螺杆菌感染方面的作用。此外,在益生菌和益生元的营养补充方面有几条研究路线开放。每种益生菌菌株都应单独和广泛地进行研究,以确定其在所有可能适用的情况下的疗效和安全性。

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