Vanderhoof J A, Young R J
Department of Pediatrics, University of Nebraska, Omaha, USA.
J Pediatr Gastroenterol Nutr. 1998 Sep;27(3):323-32. doi: 10.1097/00005176-199809000-00011.
Probiotics appear to be useful in the prevention or treatment of several gastrointestinal disorders, including infectious diarrhea, antibiotic diarrhea, and traveler's diarrhea. Results of preliminary human and animal studies suggest that patients with inflammatory diseases, and even irritable bowel syndrome, may benefit from probiotic therapy. Probiotics represent an exciting therapeutic advance, although much investigation must be undertaken before their role in gastroenterology is clearly delineated. Questions related to probiotic origin, survivability, and adherence are all important considerations for further study. More important, each probiotic proposed must be studied individually and extensively to determine its efficacy and safety in each disorder for which its use may be considered.
益生菌似乎对预防或治疗多种胃肠道疾病有用，包括感染性腹泻、抗生素相关性腹泻和旅行者腹泻。初步的人体和动物研究结果表明，患有炎症性疾病甚至肠易激综合征的患者可能从益生菌治疗中获益。益生菌代表了一项令人兴奋的治疗进展，尽管在其在胃肠病学中的作用被明确界定之前，还必须进行大量研究。与益生菌的来源、生存能力和黏附性相关的问题都是进一步研究的重要考虑因素。更重要的是，每种提议的益生菌都必须进行单独且广泛的研究，以确定其在每种可能考虑使用的疾病中的疗效和安全性。
