肠道病原体的营养和化学感应。
Nutrient and chemical sensing by intestinal pathogens.
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.
出版信息
Microbes Infect. 2013 Nov;15(12):759-64. doi: 10.1016/j.micinf.2013.06.013. Epub 2013 Jul 9.
Abstract
Pathogenic gut bacteria, such as those comprising the Enterobacteriaceae family, have evolved sophisticated virulence mechanisms, including nutrient and chemical sensing, to escape host defense strategies and produce disease. In this review we describe the mechanisms utilized by the enteric pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 to achieve successful colonization of its mammalian host.
摘要
肠道致病菌，如肠杆菌科家族的细菌，进化出了复杂的毒力机制，包括营养和化学感应，以逃避宿主防御策略并产生疾病。在这篇综述中，我们描述了肠道病原体肠出血性大肠杆菌（EHEC）O157：H7 利用的机制，以实现其在哺乳动物宿主中的成功定植。
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