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用于小动物 PET 成像的采用电流模式 CSA 的多通道前端 ASIC 的设计与特点。

Design and Characteristics of a Multichannel Front-End ASIC Using Current-Mode CSA for Small-Animal PET Imaging.

出版信息

IEEE Trans Biomed Circuits Syst. 2011 Feb;5(1):90-9. doi: 10.1109/TBCAS.2010.2095847.

DOI:10.1109/TBCAS.2010.2095847
PMID:23850981
Abstract

This paper presents the design and characteristics of a front-end readout application-specific integrated circuit (ASIC) dedicated to a multichannel-plate photodetector coupled to LYSO scintillating crystals. In our configuration, the crystals are oriented in the axial direction readout on both sides by individual photodetector channels allowing the spatial resolution and the detection efficiency to be independent of each other. Both energy signals and timing triggers from the photodetectors are required to be read out by the front-end ASIC. A current-mode charge-sensitive amplifier is proposed for this application. This paper presents performance characteristics of a 10-channel prototype chip designed and fabricated in a 0.35-μm complementary metal-oxide semiconductor process. The main results of simulations and measurements are presented and discussed. The gain of the chip is 13.1 mV/pC while the peak time of a CR-RC pulse shaper is 280 ns. The signal-to-noise ratio is 39 dB and the rms noise is 300 μV/√(Hz). The nonlinearity is less than 3% and the crosstalk is about 0.2%. The power dissipation is less than 15 mW/channel. This prototype will be extended to a 64-channel circuit with integrated time-to-digital converter and analog-to-digital converter together for a high-sensitive small-animal positron emission tomography imaging system.

摘要

本文介绍了一款前端读出专用集成电路(ASIC)的设计和特点,该集成电路专门用于与 LYSO 闪烁晶体耦合的多通道板光电倍增管。在我们的配置中,晶体沿轴向方向排列,两侧由单个光电倍增管通道进行独立读出,从而使空间分辨率和探测效率彼此独立。前端 ASIC 需要读取光电倍增管的能量信号和定时触发信号。为此应用提出了一种电流模式电荷灵敏放大器。本文介绍了一款 10 通道原型芯片的性能特点,该芯片采用 0.35μm 互补金属氧化物半导体工艺设计和制造。本文展示和讨论了模拟和测量的主要结果。芯片的增益为 13.1mV/pC,而 CR-RC 脉冲成形器的峰值时间为 280ns。信噪比为 39dB,均方根噪声为 300μV/√(Hz)。非线性小于 3%,串扰约为 0.2%。功耗小于 15mW/通道。该原型将扩展到一个 64 通道的电路,集成时间数字转换器和模数转换器,用于高灵敏度小动物正电子发射断层成像系统。

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