Jiang Tao, Deng Meng, James Roshan, Nair Lakshmi S, Laurencin Cato T
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA; Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, CT 06030, USA.
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.
Acta Biomater. 2014 Apr;10(4):1632-45. doi: 10.1016/j.actbio.2013.07.003. Epub 2013 Jul 12.
Repair and regeneration of human tissues and organs using biomaterials, cells and/or growth factors is the ultimate goal of tissue engineers. One of the grand challenges in this field is to closely mimic the structures and properties of native tissues. Regenerative engineering-the convergence of tissue engineering with advanced materials science, stem cell science, and developmental biology-represents the next valuable tool to overcome the challenges. This article reviews the recent progress in developing advanced chitosan structures using various fabrication techniques. These chitosan structures, together with stem cells and functional biomolecules, may provide a robust platform to gain insight into cell-biomaterial interactions and may function as excellent artificial extracellular matrices to regenerate complex human tissues and biological systems.
使用生物材料、细胞和/或生长因子修复和再生人体组织和器官是组织工程师的最终目标。该领域的一大挑战是紧密模拟天然组织的结构和特性。再生工程——组织工程与先进材料科学、干细胞科学和发育生物学的融合——是克服这些挑战的下一个有价值的工具。本文综述了利用各种制造技术开发先进壳聚糖结构的最新进展。这些壳聚糖结构，连同干细胞和功能性生物分子，可能提供一个强大的平台来深入了解细胞与生物材料的相互作用，并可能作为出色的人工细胞外基质来再生复杂的人体组织和生物系统。
