Chen Feiyang, Teniola O R, Laurencin Cato T
Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, Connecticut.
Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut.
J Mater Res. 2022 Apr;37(8):1417-1428. doi: 10.1557/s43578-022-00551-z. Epub 2022 Apr 18.
Regenerative engineering is a field that seeks to regenerate complex tissues and biological systems, rather than simply restore and repair individual tissues or organs. Since the first introduction of regenerative engineering in 2012, numerous research has been devoted to the development of this field. Biodegradable polymers such as polyphosphazenes in particular have drawn significant interest as regenerative engineering materials for their synthetic flexibility in designing into materials with a wide range of mechanical properties, degradation rates, and chemical functionality. These polyphosphazenes can go through complete hydrolytic degradation and provide harmlessly and pH neutral buffering degradation products such as phosphates and ammonia, which is crucial for reducing inflammation . Here, we discuss the current accomplishments of polyphosphazene, different methods for synthesizing them, and their applications in tissue regeneration such as bones, nerves, and elastic tissues.
再生工程是一个致力于再生复杂组织和生物系统的领域，而不仅仅是简单地修复和修复单个组织或器官。自2012年首次引入再生工程以来，大量研究致力于该领域的发展。特别是聚磷腈等可生物降解聚合物，因其在设计具有广泛机械性能、降解速率和化学功能的材料方面具有合成灵活性，作为再生工程材料引起了极大关注。这些聚磷腈可以进行完全水解降解，并提供无害且pH中性的缓冲降解产物，如磷酸盐和氨，这对于减轻炎症至关重要。在这里，我们讨论了聚磷腈的当前成就、合成它们的不同方法以及它们在组织再生如骨骼、神经和弹性组织中的应用。
