Department of Radiooncology and Radiotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Adv Exp Med Biol. 2013;789:203-209. doi: 10.1007/978-1-4614-7411-1_28.
This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible "targeted" therapeutic interventions.
这一章简要总结了缺氧、乳酸堆积和酸中毒影响实体恶性肿瘤恶性进展和治疗抵抗的最重要过程。虽然这些现象通常是综合反应的一部分，但在某些情况下它们可能彼此独立发生。对于可能的“靶向”治疗干预措施，后者的信息可能是相关的。
