Mohammed Saeed Walaa, Nasser Binjawhar Dalal
Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, Tayba, Medina, 42353, Saudi Arabia.
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudia Arabia.
Diabetes Metab Syndr Obes. 2023 Jul 13;16:2129-2140. doi: 10.2147/DMSO.S405476. eCollection 2023.
Hyperglycemia and insulin resistance (IR) put obese women with Type 2 diabetes mellitus (T2DM) at risk for cardiovascular disease (CVD).
150 T2DM women aged 30-45 were studied cross-sectionally at Madinah Hospital lab to find T2DM risk factors and their association with adiponectin/leptin levels.
Women with T2DM showed greater fasting blood glucose (FBG), hemoglobin A1c (HbA1c), triglycerides (TG), body mass index (BMI), waist circumference (WC), insulin resistance (IR), high-sensitivity C-reactive protein (hs-CRP), and CVD risk (high atherogenic index of plasma (AIP) and leptin), but decreased high-density lipoprotein (HDL-cholesterol) and poor insulin sensitivity with low adiponectin. Obese women with T2DM had increased leptin and reduced adiponectin. Leptin levels were significantly related to IR, BMI, and AIP (B= 3.97, P= 0.02) but not WC. Leptin levels were negatively correlated with insulin sensitivity (IS) and HDL-c (P< 0.05). In linear regression analysis, adiponectin levels had a significant association with IS and HDL-c (P= 0.03, P= 0.04) but an inverse relationship with IR, BMI, WC (B=-2.91, P= 0.04), and AIP (P< 0.05).
Increased leptin levels are related to high IR, AIP, and BMI among T2DM female patients. Similarly, adiponectin levels decrease IS and HDL-c. Therefore, obese T2DM women with high leptin and low adiponectin levels should be periodically checked to avoid or decrease consequences like CVD.
高血糖和胰岛素抵抗（IR）使患有2型糖尿病（T2DM）的肥胖女性面临心血管疾病（CVD）风险。
在麦地那医院实验室对150名年龄在30 - 45岁的T2DM女性进行横断面研究，以寻找T2DM风险因素及其与脂联素/瘦素水平的关联。
T2DM女性空腹血糖（FBG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、体重指数（BMI）、腰围（WC）、胰岛素抵抗（IR）、高敏C反应蛋白（hs - CRP）和CVD风险（血浆高致动脉粥样硬化指数（AIP）和瘦素）更高，但高密度脂蛋白（HDL - 胆固醇）降低且胰岛素敏感性差，脂联素水平低。患有T2DM的肥胖女性瘦素增加而脂联素减少。瘦素水平与IR、BMI和AIP显著相关（B = 3.97，P = 0.02），但与WC无关。瘦素水平与胰岛素敏感性（IS）和HDL - c呈负相关（P < 0.05）。在线性回归分析中，脂联素水平与IS和HDL - c显著相关（P = 0.03，P = 0.04），但与IR、BMI、WC（B = - 2.91，P = 0.04）和AIP呈负相关（P < 0.05）。
T2DM女性患者中瘦素水平升高与高IR、AIP和BMI相关。同样，脂联素水平降低IS和HDL - c。因此，瘦素水平高且脂联素水平低的肥胖T2DM女性应定期检查，以避免或减少如CVD等后果。
