Zhu Shouan, Liu Huanhuan, Wu Yan, Heng Boon Chin, Chen Pengfei, Liu Hua, Ouyang Hong Wei
Arthritis Res Ther. 2013 Jul 11;15(4):217. doi: 10.1186/ar4240.
Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of targeting Wnt and Rho GTPase for OA prognosis and therapy is suggested, which is instructive for clinical treatment of the disease.
Wnt和Rho GTPase信号传导在调控细胞生理学的诸多方面发挥着关键作用，并且已被证明参与软骨内骨化和骨关节炎（OA）的发展。在本综述中，我们对OA发展过程中经典Wnt信号传导的当前研究以及Rho GTPases在软骨细胞成熟和OA病理中的不同作用进行了批判性总结。基于当前的科学文献以及我们的初步结果，我们提出了针对Wnt和Rho GTPase进行OA预后和治疗的策略，这对该疾病的临床治疗具有指导意义。
