金黄色葡萄球菌对不同抗菌肽体外选择的差异适应性反应。
Differential adaptive responses of Staphylococcus aureus to in vitro selection with different antimicrobial peptides.
机构信息
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.
出版信息
Antimicrob Agents Chemother. 2013 Oct;57(10):5134-7. doi: 10.1128/AAC.00780-13. Epub 2013 Jul 15.
Abstract
We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.
摘要
我们让金黄色葡萄球菌 ATCC 29213 在低于最小抑菌浓度的抑菌肽 2 和短杆菌肽 D 的存在下，经过数百代的连续传代。我们获得了对抑菌肽 2（55MG 株）和短杆菌肽 D（55GR 株）产生诱导性耐药的金黄色葡萄球菌菌株，这些菌株在膜特性方面表现出不同的表型变化。两者都表现出膜磷脂含量的变化和膜刚性的增加，而与对照相比，只有 55MG 菌株的净电荷发生了改变。
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2
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3
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