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金黄色葡萄球菌对不同抗菌肽体外选择的差异适应性反应。

Differential adaptive responses of Staphylococcus aureus to in vitro selection with different antimicrobial peptides.

机构信息

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

出版信息

Antimicrob Agents Chemother. 2013 Oct;57(10):5134-7. doi: 10.1128/AAC.00780-13. Epub 2013 Jul 15.

DOI:10.1128/AAC.00780-13
PMID:23856775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3811481/
Abstract

We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.

摘要

我们让金黄色葡萄球菌 ATCC 29213 在低于最小抑菌浓度的抑菌肽 2 和短杆菌肽 D 的存在下，经过数百代的连续传代。我们获得了对抑菌肽 2（55MG 株）和短杆菌肽 D（55GR 株）产生诱导性耐药的金黄色葡萄球菌菌株，这些菌株在膜特性方面表现出不同的表型变化。两者都表现出膜磷脂含量的变化和膜刚性的增加，而与对照相比，只有 55MG 菌株的净电荷发生了改变。

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本文引用的文献

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Characterization of cell membrane parameters of clinical isolates of Staphylococcus aureus with varied susceptibility to alpha-melanocyte stimulating hormone.鉴定对 α-促黑素细胞激素敏感性不同的临床分离金黄色葡萄球菌的细胞膜参数。
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In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates.临床耐甲氧西林金黄色葡萄球菌分离株对达托霉素和宿主防御阳离子抗菌肽的体外交叉耐药性。
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C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus.α-促黑素细胞激素的 C 端氨基酸是其对抗金黄色葡萄球菌的抗菌活性所必需的。
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