Park Young-Woo, Jeong Man-Bok, Lee Eui Ri, Lee Yesran, Ahn Jae-Sang, Kim Soo-Hyun, Seo Kangmoon
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, 1 Daehak-dong, Gwanak-gu, Seoul 151-742, Korea.
J Vet Med Sci. 2013 Nov;75(11):1479-83. doi: 10.1292/jvms.13-0174. Epub 2013 Jul 16.
Central corneal thickness (CCT) can be a promising source of glaucoma monitoring and diagnosis. This study evaluated changes in CCT according to experimental adjustment of intraocular pressure (IOP) in canine eyes. To adjust and measure IOP, each eye was cannulated with two 26-gauge needles under inhalant anesthesia. One needle was connected to a pressure transducer, and the other was connected to an adjustable bag of physiologic saline. IOP was stepwise increased from 10 mmHg to 70 mmHg in 10 mmHg increments (Group T). IOP was maintained at 15 mmHg (Group C15), 30 mmHg (Group C30), 45 mmHg (Group C45), 60 mmHg (Group C60) and 75 mmHg (Group C75) during the experiment. CCT was measured with an ultrasonic pachymeter every 10 min after cannulation. There was a significant difference in the effect of time on CCT (P<0.001) and difference in CCT (dCCT; P<0.001) between groups. The CCT of group C15 remained constant during the experiment. However, group T showed an initial decrease and then an increase after passing the lowest point. Group C30 showed decreasing values for 30 min, after which the values remained constant. The values in Group C45 showed no changes for 40 min and then increased. The values in group C60 showed no change for 20 min and then increased. Group C75 showed a steady increase. In conclusion, the CCT showed two core changes according to increased IOP. This study provides essential basic data to enable further investigation into the association of IOP and CCT in dogs.
中央角膜厚度（CCT）可能是青光眼监测和诊断的一个有前景的指标。本研究评估了犬眼眼压（IOP）实验性调整后CCT的变化。为了调整和测量IOP，在吸入麻醉下，每只眼睛用两根26号针头进行插管。一根针头连接到压力传感器，另一根连接到一个可调节的生理盐水袋。IOP以10 mmHg的增量从10 mmHg逐步增加到70 mmHg（T组）。在实验过程中，IOP维持在15 mmHg（C15组）、30 mmHg（C30组）、45 mmHg（C45组）、60 mmHg（C60组）和75 mmHg（C75组）。插管后每隔10分钟用超声角膜测厚仪测量CCT。时间对CCT的影响（P<0.001）以及组间CCT差异（dCCT；P<0.001）均有统计学意义。C15组的CCT在实验过程中保持恒定。然而，T组在经过最低点后先出现下降，然后上升。C30组在30分钟内数值下降，之后保持恒定。C45组在40分钟内数值无变化，然后上升。C60组在20分钟内无变化，然后上升。C75组呈稳步上升。总之，随着IOP升高，CCT呈现出两种核心变化。本研究提供了重要的基础数据，以便进一步研究犬眼IOP与CCT之间的关联。
