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Conceptual confluence: the kynurenine pathway as a common target for ketamine and the convergence of the inflammation and glutamate hypotheses of depression.

作者信息

Miller Andrew H

机构信息

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Neuropsychopharmacology. 2013 Aug;38(9):1607-8. doi: 10.1038/npp.2013.140.

DOI:10.1038/npp.2013.140
PMID:23857540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3717552/
Abstract
摘要

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本文引用的文献

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NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice.氯胺酮阻断 NMDA 受体可消除 C57BL/6J 小鼠脂多糖诱导的抑郁样行为。
Neuropsychopharmacology. 2013 Aug;38(9):1609-16. doi: 10.1038/npp.2013.71. Epub 2013 Mar 19.
2
Connecting inflammation with glutamate agonism in suicidality.将炎症与谷氨酸激动作用联系起来以探讨自杀行为。
Neuropsychopharmacology. 2013 Apr;38(5):743-52. doi: 10.1038/npp.2012.248. Epub 2012 Dec 3.
3
Signaling pathways underlying the rapid antidepressant actions of ketamine.氯胺酮快速抗抑郁作用的信号通路。
Neuropharmacology. 2012 Jan;62(1):35-41. doi: 10.1016/j.neuropharm.2011.08.044. Epub 2011 Sep 2.
4
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?严重抑郁症与前扣带回皮质亚区小胶质细胞喹啉酸增加有关：免疫调节谷氨酸能神经传递的证据？
J Neuroinflammation. 2011 Aug 10;8:94. doi: 10.1186/1742-2094-8-94.
5
Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders.迈向抑郁谷氨酸假说：心境障碍神经精神药理学的新兴前沿。
Neuropharmacology. 2012 Jan;62(1):63-77. doi: 10.1016/j.neuropharm.2011.07.036. Epub 2011 Aug 3.
6
Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression.炎症及其相关问题：细胞因子在重度抑郁症病理生理学中的作用
Biol Psychiatry. 2009 May 1;65(9):732-41. doi: 10.1016/j.biopsych.2008.11.029. Epub 2009 Jan 15.