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多功能上转换纳米晶/聚合物纳米复合材料的合理设计用于顺铂（IV）递送和生物医学成像。

Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.

机构信息

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

出版信息

Adv Mater. 2013 Sep 20;25(35):4898-905. doi: 10.1002/adma.201301713. Epub 2013 Jul 15.

DOI:10.1002/adma.201301713
PMID:23857588
Abstract

By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.

摘要

通过将上转换纳米粒子与顺铂（IV）前药结合，我们证明了可以设计出一种稳定的多功能药物递送系统，该系统既能降低顺铂的缺点，又能深入了解其体外/体内成像。上/下转换荧光是可检测的，并显示出明显的共定位，这表明纳米粒子在细胞内相当稳定，并保留了上转换纳米粒子和嵌段共聚物。

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