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用于体内肿瘤靶向的荧光多嵌段π共轭聚合物纳米粒子。

Fluorescent multiblock π-conjugated polymer nanoparticles for in vivo tumor targeting.

机构信息

Department of Chemistry and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

出版信息

Adv Mater. 2013 Aug 27;25(32):4504-10. doi: 10.1002/adma.201301656. Epub 2013 Jun 24.

DOI:10.1002/adma.201301656
PMID:23794490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4001254/
Abstract

Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in tumor cells in vivo, thereby illustrating their potential for diagnostic and therapeutic applications.

摘要

具有叶酸表面配体的高荧光多嵌段共轭聚合物纳米粒子对于生物成像和体内肿瘤靶向非常有效。靶向纳米粒子在体内优先定位于肿瘤细胞，从而说明了它们在诊断和治疗应用中的潜力。