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用于阿霉素在体内同时递送、释放和荧光追踪的pH响应性及近红外发射聚合物纳米颗粒。

pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo.

作者信息

Yu Ji-Cheng, Chen Yu-Lei, Zhang Yu-Qi, Yao Xi-Kuang, Qian Cheng-Gen, Huang Jun, Zhu Sha, Jiang Xi-Qun, Shen Qun-Dong, Gu Zhen

机构信息

Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China.

出版信息

Chem Commun (Camb). 2014 May 11;50(36):4699-702. doi: 10.1039/c3cc49870k.

DOI:10.1039/c3cc49870k
PMID:24671329
Abstract

Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors. The BTTPF is applicable to tracking the anticancer drug release through the change of Förster resonance energy transfer efficiency between doxorubicin and BTTPF during degradation of the nanoparticles in vivo.

摘要

带有侧链缩醛修饰的葡聚糖用于负载阿霉素（DOX）和一种近红外发射共轭聚合物（BTTPF），其目的是在包括肿瘤在内的治疗靶点实现选择性药物释放。BTTPF适用于通过体内纳米颗粒降解过程中阿霉素与BTTPF之间的Förster共振能量转移效率变化来追踪抗癌药物的释放。

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