Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore; DUKE-NUS Graduate Medical School Singapore, Singapore; Department of Psychology, University of Basel, Basel, Switzerland.
Asia Pac Psychiatry. 2014 Mar;6(1):46-53. doi: 10.1111/j.1758-5872.2012.00228.x. Epub 2012 Sep 7.
The goals of the present study were to: (i) examine similarities and differences in behavioral/emotional problems manifested by children with autism spectrum disorder (ASD) and those with anxiety disorder (ANX); (ii) test the ability of each of the eight child behavioral checklist (CBCL) and teacher report form (TRF) syndrome scales to differentiate the ASD group from the ANX group; and (iii) test the ability of an ASD scale derived by Ooi et al. to differentiate the ASD group from the ANX group.
Archival CBCL and TRF data from 180 children between 4 and 18 years of age (119 males, 61 females) diagnosed with ASD (n = 86) or ANX (n = 94) at an outpatient child psychiatric clinic in Singapore were analyzed.
The ASD group scored significantly higher on Social Problems and Attention Problems but significantly lower on Anxious/Depressed and Somatic Complaints than the ANX group. The groups did not show significant differences on Withdrawn/Depressed and Thought Problems. Both the CBCL and TRF ASD scales were significant predictors of the ASD group, with moderate to high sensitivity and specificity.
Our findings for an Asian sample support the diagnostic overlap between ASD and ANX reported for Western samples and underscore the importance of treating ASD as both a unitary disease and as a web of overlapping configurations of underlying problem dimensions.
本研究的目的是：(i) 考察自闭症谱系障碍（ASD）和焦虑障碍（ANX）儿童表现出的行为/情绪问题的异同；(ii) 检验每个 8 种儿童行为检查表（CBCL）和教师报告表（TRF）综合征量表区分 ASD 组和 ANX 组的能力；(iii) 检验 Ooi 等人提出的 ASD 量表区分 ASD 组和 ANX 组的能力。
分析了新加坡一家儿童精神病门诊 180 名 4 至 18 岁（男 119 名，女 61 名）儿童的存档 CBCL 和 TRF 数据，这些儿童被诊断为 ASD（n=86）或 ANX（n=94）。
ASD 组在社会问题和注意力问题上的得分显著高于 ANX 组，而在焦虑/抑郁和躯体抱怨上的得分显著低于 ANX 组。两组在 withdrawn/Depressed 和 Thought Problems 上没有显著差异。CBCL 和 TRF 的 ASD 量表都是 ASD 组的显著预测因子，具有中等到高度的敏感性和特异性。
我们在亚洲样本中的发现支持了西方样本中报道的 ASD 和 ANX 之间的诊断重叠，并强调了将 ASD 视为一种单一疾病以及作为重叠潜在问题维度网络进行治疗的重要性。
