孕妇宫颈癌：治疗、等待还是中断？当前临床指南、创新和争议的评估。
Cervical cancer in pregnant women: treat, wait or interrupt? Assessment of current clinical guidelines, innovations and controversies.
机构信息
Leuven Cancer Institute (LKI), Gynaecologic Oncology, University Hospitals Leuven, and Department of Oncology, KU Leuven, Belgium.
出版信息
Ther Adv Med Oncol. 2013 Jul;5(4):211-9. doi: 10.1177/1758834013494988.
Abstract
Cervical cancer during pregnancy is relatively uncommon. However, the incidence is expected to increase as more women delay childbearing. When preservation of the pregnancy is desired, optimal treatment is a major challenge to all. Whereas delay of treatment is an option for pre-invasive disease, and also small invasive carcinomas without lymph node involvement, management of tumours >2 cm remains experimental. Type of treatment needs to be individualized and depends mainly on gestational age, disease stage, and histology. Extensive counselling regarding the maternal and foetal risks is required. In this current review, we aim to summarize available data and treatment guidelines concerning cervical cancer in pregnancy. Controversies and research priorities are also identified.
摘要
妊娠期宫颈癌相对少见。然而，随着越来越多的女性推迟生育，其发病率预计将会增加。当希望保留妊娠时，所有医生都面临着一个主要挑战，即如何进行最佳治疗。对于疾病处于早期且孕妇希望保留胎儿的患者，可以选择延迟治疗，也可以选择对无淋巴结转移的小体积浸润性宫颈癌延迟治疗，但是对于肿瘤直径＞2cm 的患者，治疗方法仍存在争议。治疗方法需要个体化，并主要取决于孕妇的孕周、疾病分期和组织学类型。需要对母婴风险进行广泛咨询。在本次综述中，我们旨在总结妊娠期宫颈癌的现有数据和治疗指南，并确定争议和研究重点。
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