Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Asian Pac J Allergy Immunol. 2013 Jun;31(2):132-7. doi: 10.12932/AP0294.31.2.2013.
Adenoids with obstructive hypertrophy (AH) are considered to be one of the most ancient and common problems in Paediatrics. This study aimed at investigating the expression of CD 64 on monocytes in children who had to undergo adenoidectomy.
Therefore, 66 children (24 females, 42 males, mean age 4.9 years), affected by AH and requiring adenoidectomy (54%) or adeno-tonsillectomy (46%) were consecutively enrolled into the study. Moreover, 30 healthy children (11 females, 19 males, mean age 11.2 years) were enrolled in this study as controls. CD64 expression on monocytes was measured.
Children with severe AH had higher CD64 values than children with AH size 3 and controls.
This preliminary study shows that CD64 expression on monocytes may be associated with severe AH, suggesting a more intense immune activation in these subjects.
腺样体肥大（AH）被认为是儿科最古老和最常见的问题之一。本研究旨在研究需要行腺样体切除术的儿童单核细胞上 CD64 的表达。
因此，连续纳入 66 例腺样体肥大患儿（24 名女性，42 名男性，平均年龄 4.9 岁），其中 54%的患儿行腺样体切除术，46%的患儿行腺样体扁桃体切除术。此外，本研究纳入 30 名健康儿童（11 名女性，19 名男性，平均年龄 11.2 岁）作为对照组。检测单核细胞上 CD64 的表达。
重度 AH 患儿的 CD64 值高于腺样体 3 度患儿和对照组。
这项初步研究表明，单核细胞上 CD64 的表达可能与重度 AH 相关，提示这些患儿存在更强烈的免疫激活。
