Gao Kun, Li Yanzhong, Yue Zhiyong, Han Jie, Zhou Xuanchen, Wang Xiaoting
Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan City, China.
Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan City, China.
FEBS Open Bio. 2020 May;10(5):761-766. doi: 10.1002/2211-5463.12821. Epub 2020 Mar 22.
Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor-alpha (TNF-α)-induced protein-8 like-2 (TIPE2) is a newly identified protein that negatively regulates the activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in AH in children. We observed that the levels of TNF-α and interleukin-6 were greater in the adenoid tissue of AH children than in healthy control subjects (P < 0.01), and this increase was positively correlated with the severity of AH. The level of TIPE2 expression was decreased compared with control and was negatively correlated with AH. TIPE2 overexpression in primary human monocytes (isolated from adenoid tissue of children with AH) inhibited the activation of nuclear factor-κB and the expression of TNF-α and interleukin-6. These results suggest that overexpression of TIPE2 may attenuate AH through inactivation of the nuclear factor-κB signaling pathway.
腺样体肥大（AH）是儿科人群中的一种常见病症，常见症状包括口呼吸、鼻塞、鼻音过重、打鼾和阻塞性睡眠呼吸暂停。尽管AH的发病机制尚未完全阐明，但最近的研究表明免疫反应可能在AH中起重要作用。肿瘤坏死因子-α（TNF-α）诱导蛋白8样蛋白2（TIPE2）是一种新发现的蛋白，可负向调节炎症途径的激活。在此，我们研究了TIPE2在儿童AH中的作用。我们观察到，AH患儿腺样体组织中TNF-α和白细胞介素-6的水平高于健康对照受试者（P < 0.01），且这种升高与AH的严重程度呈正相关。与对照组相比，TIPE2的表达水平降低，且与AH呈负相关。在原代人单核细胞（从AH患儿的腺样体组织中分离）中过表达TIPE2可抑制核因子-κB的激活以及TNF-α和白细胞介素-6的表达。这些结果表明，TIPE2的过表达可能通过使核因子-κB信号通路失活来减轻AH。
