Pediatric Unit, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.
J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1 Suppl):S1-7.
Adenoids removed for airway obstruction and-or recurrent infections have been studied to identify a possible mechanism to explain chronicity. In this regard, macrophages may play a relevant pathogenic role as well as neutrophils during bacterial infections and eosinophils in allergic inflammation. Therefore, this study aimed at investigating some mediators as surrogate markers of inflammation in children who had to undergo to adenoidectomy. Globally, 67 children (25 females, 42 males, mean age 4.9 years), affected by persistent obstruction caused by adenoid hypertrophy were consecutively enrolled into the study. Blood samples were collected from patients and controls to determine serum CD163, Myeloperoxidase (MPO) and ECP. There were significant differences between patients and controls for serum CD163 (p less than 0.0001); MPO (p less than 0.0001); serum ECP (p less than 0.0001). This study demonstrated some risk factors for severe AH: apnoea, recurrent respiratory infections, and high serum CD163 levels.
腺样体切除术用于治疗气道阻塞和/或反复感染，以便确定可能的发病机制。在这方面，巨噬细胞和中性粒细胞可能在细菌感染中，以及嗜酸性粒细胞在过敏炎症中发挥相关的致病作用。因此，本研究旨在调查一些介质，作为需要接受腺样体切除术的儿童炎症的替代标志物。总体而言，连续纳入了 67 名（25 名女性，42 名男性，平均年龄 4.9 岁）因腺样体肥大持续阻塞的患儿。从患者和对照组采集血样，以确定血清 CD163、髓过氧化物酶 (MPO) 和 ECP。患者与对照组之间的血清 CD163（p<0.0001）、MPO（p<0.0001）、血清 ECP（p<0.0001）存在显著差异。本研究表明，严重 AH 的一些危险因素包括：呼吸暂停、反复呼吸道感染和高血清 CD163 水平。
