心脏衰老被年轻的系统性因素逆转！
Ageing of the heart reversed by youthful systemic factors!
机构信息
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
出版信息
EMBO J. 2013 Aug 14;32(16):2189-90. doi: 10.1038/emboj.2013.162. Epub 2013 Jul 16.
Abstract
Age-associated changes in tissue maintenance and repair have severe consequences to human physiology. The signals and mechanisms that cause age-related tissue demise are unclear. A recently published study in Cell (Loffredo et al, 2013) proposes that blood-borne factors in the adult systemic environment are lost during ageing, which leads to cardiac hypertrophy. One such factor is GDF11. Exposure of aged mice to youthful systemic factors or GDF11 decreases cardiac hypertrophy of the heart.
摘要
与年龄相关的组织维持和修复的变化对人体生理学有严重的影响。导致与年龄相关的组织死亡的信号和机制尚不清楚。最近在《细胞》杂志上发表的一项研究（Loffredo 等人，2013 年）提出，成年系统环境中的血液传播因子在衰老过程中丢失，导致心脏肥大。其中一种因子是 GDF11。将老年小鼠暴露于年轻的系统因子或 GDF11 中，可减少心脏的肥大。
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