慢性二尖瓣关闭不全犬生长分化因子11（GDF11）水平的评估。
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency.
作者信息
Ahn Sung-Taek, Suh Sang-Il, Moon Hyeongsun, Hyun Changbaig
机构信息
Section of Small Animal Internal Medicine, School of Veterinary Medicine and Institute of Veterinary Medicine, Kangwon National University, Chuncheon 201-100, South Korea.
出版信息
Can J Vet Res. 2016 Jan;80(1):90-2.
Growth differentiation factor 11 (GDF11) regulates cell growth and differentiation in both embryonic and adult tissues. Circulating GDF11 levels have recently been reported to be significantly lower in aging mice and restoration of GDF11 reversed age-related cardiac hypertrophy in old mice. Here, we evaluated the potential of serum levels of GDF11 as a circulating biomarker in dogs at different stages of heart failure, due to chronic mitral valve insufficiency (CMVI). We found no significant differences in serum GDF11 levels between dogs at different stages of CMVI-associated heart failure. Furthermore, the circulating levels of GDF11 did not correlate with age, body weight, echocardiographic variables, and the severity of CMVI-induced heart failure in dogs.
生长分化因子11（GDF11）在胚胎组织和成年组织中均调节细胞生长和分化。最近有报道称，衰老小鼠体内循环GDF11水平显著降低，恢复GDF11可逆转老年小鼠与年龄相关的心脏肥大。在此，我们评估了因慢性二尖瓣关闭不全（CMVI）导致心力衰竭不同阶段的犬血清GDF11水平作为循环生物标志物的潜力。我们发现，在与CMVI相关的心力衰竭不同阶段的犬之间，血清GDF11水平无显著差异。此外，犬体内GDF11的循环水平与年龄、体重、超声心动图变量以及CMVI诱导的心力衰竭严重程度均无相关性。
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