历经磨难：一种循环生长因子抑制与年龄相关的心肌肥厚。
Through thick and thin: a circulating growth factor inhibits age-related cardiac hypertrophy.
机构信息
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Circ Res. 2013 Aug 16;113(5):487-91. doi: 10.1161/CIRCRESAHA.113.302239.
Abstract
In an intriguing new study, Loffredo et al report that joining the circulation of old mice with that of young mice reduces age-related cardiac hypertrophy. They also found that the growth factor growth/differentiation factor 11 is a circulating negative regulator of cardiac hypertrophy which suggests that raising growth/differentiation factor 11 levels may be useful to treat cardiac hypertrophy associated with aging.
摘要
在一项有趣的新研究中，Loffredo 等人报告说，将老年小鼠的循环系统与年轻小鼠的循环系统结合起来，可减少与年龄相关的心脏肥大。他们还发现，生长因子生长/分化因子 11 是心脏肥大的一种循环负调节剂，这表明提高生长/分化因子 11 的水平可能有助于治疗与衰老相关的心脏肥大。
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