Naz R K, Chaudhry A, Witkin S S
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461.
Am J Obstet Gynecol. 1990 Aug;163(2):610-3. doi: 10.1016/0002-9378(90)91211-t.
The fertilization antigen, immunopurified from human testes, activated lymphocytes from three of the six men and women with antisperm antibodies. Lymphocytes from none of the six men and women without antibodies were activated with fertilization antigen. Another sperm surface antigen, the germ cell antigen, immunopurified from murine testes, did not activate lymphocytes from any of the individuals with or without antisperm antibodies. These results indicate that the men and women with antisperm antibodies are sensitized against fertilization antigen and not germ cell antigen. These results reinforce our previous findings on the involvement of fertilization antigen in immunoinfertility in humans.
从人睾丸中免疫纯化得到的受精抗原，激活了6名患有抗精子抗体的男性和女性中的3人的淋巴细胞。6名没有抗体的男性和女性的淋巴细胞均未被受精抗原激活。另一种从鼠睾丸中免疫纯化得到的精子表面抗原——生殖细胞抗原，未激活任何有或没有抗精子抗体个体的淋巴细胞。这些结果表明，患有抗精子抗体的男性和女性对受精抗原敏感，而非生殖细胞抗原。这些结果强化了我们之前关于受精抗原参与人类免疫性不孕的研究发现。
