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半夏泻心汤治疗功能性消化不良患者消化不良症状和胃动力的随机、双盲、安慰剂对照、两中心试验。

The Effects of Banha-sasim-tang on Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial.

机构信息

College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2013;2013:265035. doi: 10.1155/2013/265035. Epub 2013 Jun 3.


DOI:10.1155/2013/265035
PMID:23861702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3686053/
Abstract

Introduction. Functional dyspepsia (FD) is highly prevalent, and no standard treatments exist for this condition. Herbal prescriptions are widely used to treat FD. In traditional Korean medicine, Banha-sasim-tang (BST) is a famous herbal prescription for dyspepsia. This study aimed to evaluate the efficacy of BST and to examine the relationship between gastric slow waves and dyspeptic symptoms. Materials and Methods. In total, 100 FD patients were recruited; BST or placebo was administered for 6 weeks. The gastrointestinal symptom scale, FD-related quality of life scale, and frequency or power variables regarding gastric slow waves were measured at 0, 6, and 14 weeks. Results. There were no significant differences in the overall dyspeptic symptoms or quality of life between the BST and placebo groups. However, early satiety was significantly improved in the BST group (P = 0.009, at 6 weeks by intention-to-treat analysis). Abnormal gastric dysrhythmias and power ratios were also significantly improved by BST. Conclusion. BST had no significant effects on FD. However, early satiety appeared to improve after BST administration. Electrogastrography may be a useful technique for assessing changes in gastric motility dysfunction after interventions for FD. Further investigation focused on specific symptoms or subtypes of FD is required.

摘要

简介。功能性消化不良(FD)的患病率很高,目前对此病尚无标准治疗方法。草药处方被广泛用于治疗 FD。在传统的韩国医学中,半夏泻心汤(BST)是一种著名的用于治疗消化不良的草药处方。本研究旨在评估 BST 的疗效,并研究胃慢波与消化不良症状之间的关系。材料与方法。共招募了 100 名 FD 患者;给予 BST 或安慰剂治疗 6 周。在 0、6 和 14 周时测量胃肠症状量表、FD 相关生活质量量表以及胃慢波的频率或功率变量。结果。BST 组和安慰剂组的整体消化不良症状或生活质量均无显著差异。然而,BST 组的早饱症状显著改善(P = 0.009,意向治疗分析在 6 周时)。BST 还显著改善了异常胃节律紊乱和功率比。结论。BST 对 FD 没有显著影响。然而,BST 给药后早饱似乎有所改善。胃电图可能是评估 FD 干预后胃动力障碍变化的有用技术。需要进一步针对特定症状或 FD 亚型进行调查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cd/3686053/f91bf00104de/ECAM2013-265035.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cd/3686053/f5f5055a7bd6/ECAM2013-265035.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cd/3686053/f91bf00104de/ECAM2013-265035.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cd/3686053/f5f5055a7bd6/ECAM2013-265035.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cd/3686053/f91bf00104de/ECAM2013-265035.002.jpg

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本文引用的文献

[1]
Efficacy of modified ban xia xie xin decoction on functional dyspepsia of cold and heat in complexity syndrome: a randomized controlled trial.

Evid Based Complement Alternat Med. 2013-3-17

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J Neurogastroenterol Motil. 2013-1-8

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Am J Gastroenterol. 2007-6

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