Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Lung. 2012 Apr;190(2):113-32. doi: 10.1007/s00408-011-9340-1. Epub 2011 Nov 3.
Sleep apnea is a common health concern that is characterized by repetitive episodes of asphyxia. This condition has been linked to serious long-term adverse effects such as hypertension, metabolic dysregulation, and cardiovascular disease. Although the mechanism for the initiation and aggravation of cardiovascular disease has not been fully elucidated, oxidative stress and subsequent endothelial dysfunction play major roles. Animal models, which have the advantage of being free of comorbidities and/or behavioral variables (that commonly occur in humans), allow invasive measurements under well-controlled experimental conditions, and as such are useful tools in the study of the pathophysiological mechanisms of sleep apnea. This review summarizes currently available information on the cardiovascular consequences of sleep apnea and briefly describes common experimental approaches useful to sleep apnea in different animal models.
睡眠呼吸暂停是一种常见的健康问题，其特征是反复发生窒息。这种情况与严重的长期不良后果有关，如高血压、代谢失调和心血管疾病。尽管心血管疾病的发生和加重机制尚未完全阐明，但氧化应激和随后的内皮功能障碍起着重要作用。动物模型具有无合并症和/或行为变量（常见于人类）的优势，可以在严格控制的实验条件下进行侵入性测量，因此是研究睡眠呼吸暂停病理生理机制的有用工具。这篇综述总结了目前关于睡眠呼吸暂停对心血管影响的信息，并简要描述了不同动物模型中用于睡眠呼吸暂停的常用实验方法。
