Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Clin Invest. 2013 Jul;123(7):2756-63. doi: 10.1172/JCI69219. Epub 2013 Jul 1.
Immunotherapy can be an effective treatment for metastatic cancer, but a significant subpopulation will not respond, likely due to the lack of antigenic mutations or the immune-evasive properties of cancer. Likewise, radiation therapy (RT) is an established cancer treatment, but local failures still occur. Clinical observations suggest that RT may expand the therapeutic reach of immunotherapy. We examine the immunobiologic and clinical rationale for combining RT and immunotherapy, two modalities yet to be used in combination in routine practice. Preclinical data indicate that RT can potentiate the systemic efficacy of immunotherapy, while activation of the innate and adaptive immune system can enhance the local efficacy of RT.
免疫疗法可为转移性癌症提供有效的治疗手段，但相当一部分患者对此没有反应，其原因可能是缺乏抗原突变或肿瘤的免疫逃避特性。同样，放射疗法（RT）是一种已确立的癌症治疗方法，但仍会出现局部复发。临床观察表明，RT 可能会扩大免疫疗法的治疗范围。我们研究了 RT 和免疫疗法联合应用的免疫生物学和临床原理，这两种方法尚未在常规实践中联合使用。临床前数据表明，RT 可以增强免疫疗法的全身疗效，而固有和适应性免疫系统的激活可以增强 RT 的局部疗效。
