Division of Infectious Diseases, Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea.
Korean J Intern Med. 2013 Jul;28(4):403-7. doi: 10.3904/kjim.2013.28.4.403. Epub 2013 Jul 1.
Vaccines against fungal diseases are gaining attention because of their growing impact on modern medicine. Development of these vaccines should incorporate immunological tools that integrate with or replace chemotherapy to minimize antibiotic use and consequent resistance. In this review, we evaluate the current developmental status of fungal vaccines against coccidioidomycosis. There is a need for a vaccine that sufficiently prevents disease, without eradicating the fungus, by neutralizing adhesions and enzymes or other low penetrance virulence traits.
由于真菌病对现代医学的影响日益增加，针对这些疾病的疫苗越来越受到关注。这些疫苗的开发应该结合或替代化疗的免疫工具，以最大限度地减少抗生素的使用和由此产生的耐药性。在这篇综述中，我们评估了针对球孢子菌病的真菌疫苗的当前发展状况。需要有一种疫苗，通过中和黏附素和酶或其他低穿透力的毒力特征，既能充分预防疾病，又能不根除真菌。
