Holzhütter H G, Heinrich R
Institute of Biochemistry, Humboldt-University Berlin, GDR.
Biomed Biochim Acta. 1990;49(2-3):S154-9.
A theoretical approach is presented to predict the structural design of enzymatic reaction systems. It is based on the hypothesis that the kinetic properties of enzymes and of other functionally important proteins have been optimized during evolution so that the contemporary cellular metabolic systems are operating at an optimal state. As simple but instructive example we consider the optimization of the stationary flux rate of a single enzyme. In contrast to previous studies a more realistic enzymatic rate equation has been chosen according to HALDANE's reaction scheme.
提出了一种理论方法来预测酶促反应系统的结构设计。它基于这样的假设：酶和其他功能重要蛋白质的动力学特性在进化过程中已得到优化，从而使当代细胞代谢系统处于最佳运行状态。作为一个简单但有启发性的例子，我们考虑单一酶的稳态通量率的优化。与先前的研究不同，根据霍尔丹反应方案选择了一个更现实的酶促速率方程。
