Yahya Raida S, Sofan Mamdouh A, Abdelmasseih Hanaa M, Saudy Niveen, Sharaf-Eldein Mohamed A
Children Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Clin Lab. 2013;59(5-6):621-8. doi: 10.7754/clin.lab.2012.120604.
Recently various molecular markers and global gene expression profiling have been investigated to improve risk profile characterization of AML with normal cytogenetics. Our main objective is to investigate the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) expression in AML with normal karyotype.
BAALC expression was analysed using quantitative real time (QRT) PCR.
High expression was detected in 22 of 45 patients (48.9%) and its expression did not correlate with the clinical parameters of patients. High BAALC expressers had significantly lower incidence of CR (22.7% vs. 73.9%; p = 0.001), higher mortality rate (72.1% vs. 39.1%; p = 0.023), showed significantly shorter DFS (mean 4.5 vs. 13.21 months, p < 0.001), and inferior overall survival (7.02 vs. 15.02 months, p < 0.001). Multivariable analysis confirmed high BAALC expression as an independent risk factor for DFS and OS.
BAALC expression is an important prognostic factor in AML patients with normal karyotype and its incorporation into novel risk-adapted therapeutic strategies will improve the currently disappointing cure rate of this group of patients.
最近，人们对各种分子标志物和全基因表达谱进行了研究，以改善对核型正常的急性髓系白血病（AML）风险特征的描述。我们的主要目的是研究脑和急性白血病、细胞质（BAALC）表达对核型正常的AML患者的预后影响。
使用定量实时（QRT）PCR分析BAALC表达。
45例患者中有22例（48.9%）检测到高表达，其表达与患者的临床参数无关。BAALC高表达者的完全缓解（CR）发生率显著较低（22.7%对73.9%；p = 0.001），死亡率较高（72.1%对39.1%；p = 0.023），无病生存期（DFS）显著缩短（平均4.5个月对13.21个月，p < 0.001），总生存期较差（7.02个月对15.02个月，p < 0.001）。多变量分析证实BAALC高表达是DFS和总生存期（OS）的独立危险因素。
BAALC表达是核型正常的AML患者的重要预后因素，将其纳入新的风险适应性治疗策略将提高这组患者目前令人失望的治愈率。
