Amirpour Mojgan, Ayatollahi Hossein, Sheikhi Maryam, Azarkerdar Somaye, Shams Seyyede Fatemeh
MSc student of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran.
MD, Associate Professor of Hematopathology, Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Med J Islam Repub Iran. 2016 Sep 27;30:418. eCollection 2016.
Acute myeloid leukemia (AML) is known as one of the most common leukemia among adults. Environmental and different genetic factors affect disease process, prognosis and treatment. Among different genetic factors NPM1, FLT3, MLL and BAALC genes are the most effective on patient's survival rate. The aim of this study was to assess amount of BAALC gene expression in AML patients, and its relation to survival rate. In this case-control study, from all 94 individuals referred to Ghaem Medical Center during 2012-2015, 47 cases were normal cytogenetic AML and others were healthy individuals that were studied as control group. Real-time PCR method was applied for gene expression evaluation. Other information of patients was extracted from medical documents. SPSS v.21 was used for data processing. Mean age of studied cases was 31.50 years. The most of BAALC gene expression was seen in M1 and M2 subtypes, and the less was in M5. A significant relation was found between amount of gene expression and patient's survival rate. BAALC gene expression was increased significantly in AML cases. BAALC expression had reverse relation with patients' survival rate in North-East of Iran.
急性髓系白血病（AML）是成人中最常见的白血病之一。环境因素和不同的遗传因素会影响疾病进程、预后和治疗。在不同的遗传因素中，NPM1、FLT3、MLL和BAALC基因对患者生存率影响最大。本研究旨在评估AML患者中BAALC基因的表达量及其与生存率的关系。在这项病例对照研究中，从2012年至2015年转诊至加姆医学中心的所有94名个体中，47例为正常细胞遗传学AML患者，其余为健康个体作为对照组。采用实时聚合酶链反应（PCR）方法评估基因表达。患者的其他信息从医疗文件中提取。使用社会科学统计软件包（SPSS）v.21进行数据处理。研究病例的平均年龄为31.50岁。BAALC基因表达在M1和M2亚型中最高，在M5中最低。发现基因表达量与患者生存率之间存在显著关系。AML病例中BAALC基因表达显著增加。在伊朗东北部，BAALC表达与患者生存率呈负相关。
