Devasagayam T P, Sivabalan R, Tarachand U
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Biochem Int. 1990;21(1):27-32.
The influence of deciduoma-induced differentiation on the lipid peroxidation in the rat uterus was investigated. The wet weight of uterus and its protein content increased during deciduoma progression. Content of the thiobarbituric acid reactive substances (TBARS) as well as lipid peroxidation induced by ascorbate and cumene hydroperoxide showed significant decreases during deciduoma growth. Restoration of normalcy was observed during regression. The activity of superoxide dismutase, an inhibitor of lipid peroxidation showed an opposite pattern namely increase during deciduoma development and decline during the regressive phase. We conclude that cell differentiation during deciduoma induction is accompanied by a temporary and reversible decrease in the peroxidative potential of the rat uterus.
研究了蜕膜瘤诱导分化对大鼠子宫脂质过氧化的影响。在蜕膜瘤进展过程中，子宫湿重及其蛋白质含量增加。硫代巴比妥酸反应性物质（TBARS）的含量以及抗坏血酸和异丙苯过氧化氢诱导的脂质过氧化在蜕膜瘤生长期间显著降低。在退化过程中观察到恢复正常。超氧化物歧化酶（一种脂质过氧化抑制剂）的活性呈现相反的模式，即在蜕膜瘤发展期间增加，在退化阶段下降。我们得出结论，蜕膜瘤诱导过程中的细胞分化伴随着大鼠子宫过氧化潜能的暂时和可逆性降低。
