肺脏炎症中的 2 型固有淋巴细胞。
Group 2 innate lymphoid cells in lung inflammation.
机构信息
Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
出版信息
Immunology. 2013 Nov;140(3):281-7. doi: 10.1111/imm.12153.
Abstract
Although allergic asthma is a heterogeneous disease, allergen-specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, interleukin-4 (IL-4), IL-5 and IL-13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen-induced asthma.
摘要
尽管变应性哮喘是一种异质性疾病，但被认为在哮喘发病机制中起主要作用的是产生涉及 2 型炎症的关键细胞因子的过敏原特异性辅助性 T 细胞 2（Th2）细胞，这些细胞因子包括白细胞介素-4（IL-4）、IL-5 和 IL-13。这一模型受到了最近发现的 2 组先天淋巴细胞（ILC2）的挑战，它们是 2 型细胞因子的关键先天来源。这些 ILC2 被上皮细胞衍生的细胞因子激活，包括 IL-25 和 IL-33，它们被认为参与了哮喘的发生。在这篇综述中，我们将讨论支持 ILC2 在肺部炎症中具有重要作用的最新研究，特别关注过敏原诱导的哮喘。
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