[Pentacam 眼前节分析系统 Scheimpflug 摄影及 Visante 光学相干断层扫描测量角膜厚度的重复性与一致性]

[Repeatability and agreement of corneal thickness measurement with Pentacam Scheimpflug photography and Visante optical coherence tomography].

作者信息

Huang Jin-hai, Ge Li-na, Wen Dai-zong, Chen Shi-hao, Yu Ye, Wang Qin-mei

机构信息

School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2013 Mar;49(3):250-6.

PMID:23866707

Abstract

OBJECTIVE

To evaluate the repeatability and agreement of central and peripheral corneal thickness (CT) measurements by high resolution Pentacam rotating Scheimpflug photography and Visante optical coherence tomography (OCT) in unoperated myopic eyes and eyes after Laser In Situ Keratomileusis (LASIK).

METHODS

CT at central, thinnest, 1.0 mm and 2.5 mm superior, inferior, nasal and temporal periphery locations, and the location of the corneal thinnest thickness were measured using Pentacam and Visante OCT in 60 myopia patients (60 eyes) and 60 patients (60 eyes) after LASIK. The results were analyzed by paired-t test, Pearson correlation analysis and Bland-Altman method.

RESULTS

Both Pentacam and Visante OCT demonstrated high intraobserver repeatability, with all intraclass correlation coefficients and Cronbach's alphas were more than 0.9, and coefficient of variation were less than 0.9%. Significantly higher CoV was measured with Pentacam than by Visante OCT in at central (0.46 ± 0.30), thinnest (0.43 ± 0.28) and 1.0 mm locations in both groups (t = 2.465, 2.226, P < 0.05), but no statistically significant difference were found at 2.5 mm locations in healthy subjects and all locations in post-LASIK eyes (t = -0.518, 1.542, -0.876, 0.756, P > 0.05). The thickness of central corneal with Pentacam was (543.01 ± 22.89) µm, the thinnest point was (540.61 ± 22.84) µm, they were greater than the value of Visante OCT (t = 17.946, 23.071, P < 0.05). The Pearson correlation coefficients were all more than 0.9 (all r > 0.9, P < 0.01). The Bland-Altman plots showed the 95% LoA between both devices were lower than 22 µm at central, thinnest and 1.0 mm locations. However, the 95% LoA were 24 µm to 44 µm at 2.5 mm locations.

CONCLUSIONS

Pentacam and Visante OCT demonstrate high repeatability for central and peripheral CT measurements in young myopia and post-LASIK eyes. However, both devices can't be used interchangeably for measurements of peripheral CT.

摘要

目的

评估在未手术的近视眼和准分子原位角膜磨镶术（LASIK）术后眼中，使用高分辨率Pentacam旋转式Scheimpflug摄影仪和Visante光学相干断层扫描（OCT）测量中央和周边角膜厚度（CT）的可重复性及一致性。

方法

使用Pentacam和Visante OCT测量60例近视患者（60只眼）和60例LASIK术后患者（60只眼）的中央、最薄处、上方、下方、鼻侧和颞侧周边1.0 mm及2.5 mm处的角膜厚度，以及角膜最薄厚度的位置。结果采用配对t检验、Pearson相关分析和Bland - Altman方法进行分析。

结果

Pentacam和Visante OCT均显示出较高的观察者内可重复性，所有组内相关系数和Cronbach's α系数均大于0.9，变异系数均小于0.9%。在两组的中央（0.46±0.30）、最薄处（0.43±0.28）和1.0 mm位置，Pentacam测量的变异系数显著高于Visante OCT（t = 2.465，2.226，P < 0.05），但在健康受试者的2.5 mm位置和LASIK术后眼的所有位置差异无统计学意义（t = -0.518，1.542， -0.876，0.756，P > 0.05）。Pentacam测量的中央角膜厚度为（543.01±22.89）µm，最薄点为（540.61±22.84）µm，均大于Visante OCT测量值（t = 17.946，23.071，P < 0.05）。Pearson相关系数均大于0.9（所有r > 0.9，P < 0.01）。Bland - Altman图显示，在中央、最薄处和1.0 mm位置，两种设备之间的95%一致性界限低于22 µm。然而，在2.5 mm位置，95%一致性界限为24 µm至44 µm。